Extended Data Fig. 8: DNA methylation levels in various tissues and differences in DNA methylation in the regions nearby source elements and whole-genomes of colorectal clones.
From: Widespread somatic L1 retrotransposition in normal colorectal epithelium
a, Average level of L1 promoter DNA methylation across different tissues from ENCODE. Among 30 rc-L1s described in Fig. 3b, only 12 rc-L1s with sufficient reads in all tissues were selected. b, Methylation profiles of 100 kb upstream and downstream regions of 6 reference rc-L1s with variable methylation levels in colorectal clones. The region for rc-L1 is highlighted with yellow boxes. The genomic coordinates and order of CpG sites are depicted in the top panel. Middle panel shows the fraction of methylated CpG in colorectal clones with open (orange) and closed (blue) promoters. Bottom panel shows the differences in the fraction of methylated CpG depicted in the middle panel. mCpG, methylated CpG. c, A scatter plot showing genome-wide methylation levels of normal colorectal clones in each individual.
