Fig. 4: Breakpoint and rate acceleration of somatic L1 retrotranspositions.
From: Widespread somatic L1 retrotransposition in normal colorectal epithelium
a,b, Schematic diagrams of genomic structures of canonical and complex L1 insertions (a) and underlying mechanisms (b). RT body, retrotransposed body; DSB, double-strand break. c, Phylogeny of MUTYH-associated adenomatous clones with normalized L1 rates in groups of lineages classified by driver mutations. Branch lengths are proportional to molecular time, as measured by the number of somatic point mutations. Numbers of branch-specific soL1Rs and branch-specific driver mutations are shown.
