Fig. 5: Landscape of somatic L1 retrotranspositions. | Nature

Fig. 5: Landscape of somatic L1 retrotranspositions.

From: Widespread somatic L1 retrotransposition in normal colorectal epithelium

Fig. 5

Schematic diagram illustrating factors influencing the soL1R landscape. Genetic composition of rc-L1s is inherited from the parents. The methylation landscape of rc-L1 promoters is predominantly determined by global DNA demethylation, followed by remethylation processes in the developmental stages. Then, when an rc-L1 is promoter demethylated in a specific cell lineage, the source expresses L1 transcripts thus making possible the induction of soL1Rs.

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