Extended Data Fig. 3: SoL1Rs on the developmental phylogenies of the clones from the seven individuals with early embryonic soL1R events.

Early phylogenies of colorectal clones and the matched cancer tissue are shown in seven individuals who have shared soL1Rs among clones. Branch lengths are proportional to the molecular time measured by the number of somatic point mutations. The numbers of branch-specific point mutations are shown with numbers. The filled circles at the ends of branches represent normal clones (black-filled circles) and cancer clones (red-filled circles). The numbers within the filled circles show the number of soL1Rs detected from the clones. Shaded areas indicate somatic lineages with shared soL1Rs. The genomic ___location of the shared soL1R insertions and the proportion of the blood cells carrying the soL1Rs are shown by genomic coordinates and pie charts. Coloured bars on the right side represent the proportion of mutational signatures attributable to the somatic point mutations. Orange diamonds show L1 sources (origin), which caused transduction events across the colorectal clones.