Extended Data Fig. 4: SoL1Rs on the developmental phylogenies of the clones from the 12 individuals without early embryonic soL1R events.

Early phylogenies of colorectal clones and the matched cancer tissue are shown in 12 individuals who have no shared soL1Rs among clones. Branch lengths are proportional to the molecular time measured by the number of somatic point mutations. The numbers of branch-specific point mutations are shown with numbers. The filled circles at the ends of branches represent normal clones (black-filled circles) and cancer clones (red-filled circles). The numbers within the filled circles show the number of soL1Rs detected from the clones. Shaded area indicates somatic lineages with shared Alu insertion. The genomic ___location of the shared Alu insertion and the proportion of the blood cells carrying the Alu insertion are shown by genomic coordinates and a pie chart. Coloured bars on the right side represent the proportion of mutational signatures attributable to the somatic point mutations. Orange diamonds show L1 sources (origin), which caused transduction events across the colorectal clones.