Extended Data Fig. 2: Copy-number alteration analysis of Patient 7 and 9 whole-exome sequencing data.
From: Ultraviolet radiation shapes dendritic cell leukaemia transformation in the skin
a, Genome plots show B (minor) allele frequencies (left) and read coverage (right) for single-nucleotide variants (SNVs) detected in the Patient 7 germline sample using whole-exome sequencing. Heterozygous SNVs (A/B) are indicated in red, homozygous SNVs (B/B) are indicated in green. The same SNVs are shown for the bone marrow and skin tumour samples, indicating copy-number alterations specific to the skin tumour. A focal loss detected on chr2q is indicated by arrows. b, Genome plots show similar analysis for germline, bone marrow, and skin tumour samples of Patient 9. A sub-clonal copy-number neutral loss of heterozygosity (LOH) on chr7q was detected in the uninvolved bone marrow sample, which was not detected in the skin tumour. Related to Fig. 1.
