Extended Data Fig. 10: Effects of Treg co-transplantation with C4-mDAPs in an autologous C4-humanized model of PD.
From: Co-transplantation of autologous Treg cells in a cell therapy for Parkinson’s disease
a–h, C4-humanized mice were killed eight weeks after intra-striatal co-transplantation of C4-mDAPs with or without autologous C4-Treg cells (20,000 cells per mouse). a, Schematic overview of experimental design. b, Survival of C4-humanized mice. Total number of transplanted C4-mDAPs (c), graft volume (d) and TH+ cells (g) were assayed. Number of Ki67+ (e) and correlation between Ki67+ and hNUCLEI+ cell number (f). (Two-tailed correlation). h, The levels of hCD4+ T cells in all three mice in +Treg cells group were confirmed through immunofluorescence staining. (Two-tailed unpaired t-test; Mann–Whitney post-hoc test; n = 2 (−Treg cells) or 3 (+Treg cells) per group).
