Extended Data Fig. 11: Sst44 cells in retrosplenial cortex do not activate during corrections for heading deviations.
From: A cell-type-specific error-correction signal in the posterior parietal cortex
a, Activity in RSC and behaviour averaged over large bursts of Sst44 cell activity (smoothed Sst44 cell activity > 0.4). b, Activity and behaviour as the mouse entered the T-junction, split based on whether this was followed by a large (> π/6) or a small (< π/12) heading deviation. Left and right deviations were pooled after inverting behaviour for left deviations. Selection criteria were evaluated at +1.5 s after entering the T-junction. c, Same as b, splitting trials with a high deviation based on whether the mouse corrected strongly (turning acceleration > 1 rad/s2 in the opposite direction) or weakly (< 0.50 rad/s2). d, Pearson correlation between cells of each cell type. Kolmogorov-Smirnov test, Sst44+/Sst44+ pair vs other cell type pairs, p < 0.01. e, UMAP projection of each cell’s activity from a sample session, showing clustering of Sst44 neurons. f, Fraction of 10 nearest neighbours in activity space that are Sst44+. Dashed line: mean after shuffling cell type identities. ** p < 0.01, Kolmogorov-Smirnov test. These data for RSC were collected on interleaved PPC sessions from the same mice as in Fig. 5. In d–f, activity was smoothed with a 0.25 s gaussian filter. 7 mice, 23 sessions. Mean and bootstrapped 95% confidence intervals are shown.
