Fig. 5: Sst44 cells in the PPC activate during navigational course corrections.

a, Imaging activity during virtual T-maze navigation. b, Sst44 cell activity during a smooth trajectory towards the reward. Accel., turning acceleration; dev., heading deviation. c, Sst44 activity as in b, but during a trial with a course correction, highlighting high Sst44 cell activity. d,e, Trajectories of the trials in b and c, respectively. f, Sample trace of the mean cell type activities. g, Behaviour triggering on bursts of Sst44 cell activity. h, Activity triggered on entering the T-junction, split by large and small heading deviations. Left and right deviations were pooled after inverting behaviour for left deviations. i, Activity triggered on entering the T-junction as described in h, but splitting high-deviation trials by strong and weak corrections. j, Activity triggered on turning accelerations, with high turning velocity (to match the turning profile across conditions), split by large and small deviations. Left and right turning accelerations were pooled after inverting behaviour for right accelerations. For h–j, statistical analysis was performed using Wilcoxon rank-sum tests across trials for Sst44 cell activity (solid versus dashed line, P < 1 × 10⁻¹⁰), and Wilcoxon signed-rank tests across trials for Sst44 cell activity versus the other cell types (P < 1 × 10⁻¹⁰). Activity averaged over 0.5 to 2.5 s relative to −1 to 0 s was used for statistical analyses. Data are mean ± bootstrapped 95% confidence intervals. n = 7 mice, 27 sessions.