Extended Data Fig. 7: Sequence alignment of human GRKs.
From: GPCR activation and GRK2 assembly by a biased intracellular agonist
The N-terminal helix (αN) is highlighted in red. The RHD is highlighted in green and KD is in light blue. The AST loop extended from the kinase ___domain is in light purple. The PHD of GRK2 and GRK3 are in pink. N-terminal lipid binding ___domain (NLBD) and C-terminal lipid binding ___domain (NLBD) according to GRK5 are highlighted in dark yellow and light green, respectively. Residues that may interact with membrane lipid are highlighted in dark blue. And residues from GRK2 that interact with NTSR1 are highlighted in yellow. α, α helix. β, β strand.
