Extended Data Fig. 8: Structural comparison of NTSR1–GRK2–Gαq complex with NTSR-Gi complex and other GPCR-G protein complexes. | Nature

Extended Data Fig. 8: Structural comparison of NTSR1–GRK2–Gαq complex with NTSR-Gi complex and other GPCR-G protein complexes.

From: GPCR activation and GRK2 assembly by a biased intracellular agonist

Extended Data Fig. 8

Superposition of the receptor TMD fragment from different GPCR complexes showed that the active GPCRs had very similar 3D architecture, and the ___location of α5 helix from different G proteins overlapped with the N-terminal helix of GRK2.

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