Extended Data Fig. 5: Structure comparisons of the active state and inactive state of PTH1R induced by different ligands.
From: Conserved class B GPCR activation by a biased intracellular agonist
(a–d) Structure comparisons are between the active state complexes with PTH and with PCO371. Superimposition of PTH1R from PDB: 8HA0 (PTH1R: royal blue, PTH: light coral) and the PCO371-bound PTH1R structure (PTH1R: light sea green, PCO371: crimson) reveals different peptide- and PCO371-binding sites. (a–b) Side view of different binding pockets and conformational changes in receptors; (c) Extracellular view and (d) intracellular view of PTH1R conformational changes. (e–h) Superimposed structures of PCO371-bound PTH1R in the active state, and ePTH-bound PTH1R in the inactive state from PDB: 6FJ3 (PTH1R: dark gray, ePTH: dark khaki) and the PCO371-bound PTH1R structure (PTH1R: light sea green, PCO371: crimson). (e–f) Side view of different binding pockets and conformational changes in receptors; (g) Extracellular view and (h) intracellular view of PTH1R conformational changes.
