Extended Data Fig. 7: Changes in PSD composition during macaque and mouse neocortical development.

a, UpSet plot describing the number of identified proteins and their overlaps at each age group of macaque and mouse datasets. b, PCA plots of the macaque and mouse samples colored by their age groups. c, Hierarchical clustering of macaque and mouse samples based on proteins with differential abundance. d, Preservation of Human PSD modules in macaque and mouse PSD proteomic data. e, Gene set enrichment analysis (GSEA) for individual age groups across human V1, macaque, and mouse samples. NES, normalized enrichment score. Nominal P values were adjusted by the Benjamini and Hochberg method. f, Similarity matrices representing pairwise Pearson correlations between human V1, macaque, and mouse samples. g, Standardized abundance patterns of proteins in the four PSD modules (n = 127, 169, 159 and 178 proteins) across regions and species along the humanized age based on the human V1 dataset. Data are presented as mean values ± s.e.m. The macaque and mouse illustrations were created with BioRender.com.