Extended Data Fig. 10: Association of PSD modules with cognitive functions and brain disorders.

a, PPI-co-abundance network of the turquoise module with activity-dependent proteins highlighted. b, Distribution of gnomAD synonymous Z-scores of genes in each category (n = 265, 313, 402, 224, 561, 1765 and 12892 genes). Boxplot center: median; hinges: the 25th and 75th percentiles; whiskers: 1.5 × inter-quartile range. The P values were obtained from Kruskal–Wallis test with Dunn’s multiple comparisons test; ns, not significant. c, Percentage of rare variants located at PSD module genes in subjects with or without neurodevelopmental disorders. d, PPI-co-abundance network of the turquoise module with genes carrying neurodevelopmental disorder-linked (at least 3) de novo missense variants or (at least 2) PTVs highlighted. e, PPI-co-abundance network of the brown module with genes carrying psychiatric disorder-linked common variants highlighted. f, PPI-co-abundance network of the yellow module with genes downregulated in psychiatric disorders highlighted. g, Volcano plots for misexpressed genes after the onset of psychiatric disorders in PSD modules. Red dots indicate differentially expressed genes with the Benjamini–Hochberg adjusted P values < 0.05.