Extended Data Fig. 3: Protein modules of the developing human PSD.
From: A cross-species proteomic map reveals neoteny of human synapse development

a, Kernel density estimation of the null distributions of protein-protein interaction (PPI) numbers assuming no enrichment of PPI in individual modules; the vertical red lines indicate the observed PPI numbers in each module. The exact P value was derived from the one-tailed permutation test. b, SynGO biological pathway enrichment analysis of each module. Nominal P values from Fisher’s exact test were adjusted by the Benjamini and Hochberg method. c, PPI-co-abundance network of the four PSD modules. d, PPI-co-abundance network of each module highlighting proteins in enriched pathways. e, The normalized average shortest path lengths of pathways in individual modules. The asterisks denote that the average shortest path length is significantly shorter within pathway proteins than between pathway and non-pathway proteins. The P values were obtained from one-tailed Wilcoxon rank sum test; *P < 0.01.