Extended Data Fig. 6: AC484 induces a unique CD8+ effector T cell state.
From: The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity
a, Heatmap showing top 15 differentially expressed genes in each cluster by one vs. rest test with representative genes from each cluster shown on the y axis. b, Relative expression of lineage and CD8+ T cell subset markers among re-clustered lymphoid cells expressing Cd8a, Ncr1, or Cd4 from Fig. 5a. c, Box plots of proportional changes by cluster of lymphoid cells by treatment. d, UMAP projections showing capture and expression of Gzmb (top), Prf1 (middle) and Ifng (bottom), downsampled for an equal number of cells across conditions. e, Bar plot showing scoring of a previously published effector T cell geneset (GSE9650_NAIVE_VS_EFF_CD8_TCELL_DN) in all clusters with captured Cd8a transcript averaged by replicate (left). Bar plot showing scoring of the Hallmark IL-2/STAT5 Signaling gene set in all clusters with captured Cd8a transcript averaged by replicate (right).
