Extended Data Fig. 11: Stacked regional association plots between COVID loci and pQTLs. | Nature

Extended Data Fig. 11: Stacked regional association plots between COVID loci and pQTLs.

From: Plasma proteomic associations with genetics and health in the UK Biobank

Extended Data Fig. 11

(a) Regional association between COVID-19 locus at MUC5B and SFTPD, LAMP3 trans pQTLs (b) Regional association between COVID-19 locus at TYK2 and colocalized IL12RB1 trans pQTL, in addition to the cis pQTLs of ICAM-1,3,4 and 5 in close proximity. (a) and (b) P-values derived from REGENIE regression GWAS (two-sided, unadjusted). (c) The IL12R-TYK2 inflammatory response signalling schematic with red asterisk indicating the trans pQTL for IL12RB1 in TYK2. Figure created with BioRender.com.

Back to article page