Extended Data Fig. 5: 3D variability analysis of the apo and 1-up HKU1-A data sets. | Nature

Extended Data Fig. 5: 3D variability analysis of the apo and 1-up HKU1-A data sets.

From: Sialoglycan binding triggers spike opening in a human coronavirus

Extended Data Fig. 5

3D variability analysis of the symmetry expanded apo HKU1-A particles indicated that there are no detectable open S1B domains present in the data. In contrast, this method could discriminate between open and closed S1B domains in the holo 1-up data set, used as control to show the validity of this approach. The region which was masked during the analysis is circled.

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