Extended Data Fig. 1: Dose-response curves of nirmatrelvir and ensitrelvir inhibiting Mpros.
From: Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir
Curves of each compound inhibiting 8 Mpros are sorted into 3 groups based on the ___location of the substitutions. a, Dose-response curves of nirmatrelvir inhibiting E166V, F140L, and S144A. b, Dose-response curves of nirmatrelvir inhibiting T21I, T21I/E166V, and L50F/E166V. c, Dose-response curves of nirmatrelvir inhibiting L167F and A193P. d, Dose-response curves of ensitrelvir inhibiting E166V, F140L, and S144A. e, Dose-response curves of ensitrelvir inhibiting T21I, T21I/E166V, and L50F/E166V. f, Dose-response curves of ensitrelvir inhibiting L167F and A193P. Dose-response curves of nirmatrelvir or ensitrelvir inhibiting WT Mpro are also shown in these panels. Data points are shown as mean ± SD for biological quadruplicates. Note that for panels c and f, the curves of L167F and A193P are overlapping very closely with each other.
