Extended Data Fig. 3: Ribbon models of Crt-TIR, Crt-pPAZ and Crt-Ago and secondary-structure diagrams.
From: Nucleic-acid-triggered NADase activation of a short prokaryotic Argonaute
a, Top, cryo-EM density map of Crt-SAPARTA heterodimer (white) with the TIR ___domain highlighted in light blue. Bottom, ribbon model of Crt-TIR using the same colour code; secondary structures are labelled. b, Secondary-structure diagram of Crt-TIR; TIR core ___domain is highlighted with a dashed box. c, Top, cryo-EM density map of Crt-SAPARTA heterodimer (white) with the N-like ___domain highlighted in cyan, linker ___domain highlighted in grey and trigger ___domain highlighted in dark blue. Bottom, ribbon model of Crt-pPAZ with the secondary structures labelled. d, Secondary-structure diagram of Crt-pPAZ; linker ___domain is composed of L0, L1 and L2, which are indicated by dashed regions. e, Top, cryo-EM density map of Crenotalea thermophila (Crt) SAPARTA heterodimer; Crt-Ago is highlighted by pink (MID) and magenta (PIWI), whereas the rest of the complex is coloured white. Bottom, ribbon model of Crt-Ago with the secondary structures labelled. f, Secondary-structure diagram of Crt-Ago.
