Extended Data Fig. 7: TrkB isoform expression in DIPG.
From: Glioma synapses recruit mechanisms of adaptive plasticity
a, Heatmap of single-cell RNASeq data of patient derived glioma xenograft models (SU-DIPG-VI and SU-DIPG-XIII) cells (n = 321 cells, 4 mice) demonstrating relative expression of TrkB (NTRK2) isoforms; Full (ENST-277120.7 and ENST-323115.9) and Truncated (527aa ENST-376208.5 and ENST-376208.5; 477aa ENST-359847 and ENST-395882.5), with representative Ensembl codes depicted below. b, Violin plots of relative expression level of TrkB isoforms (depicted in a,) for both SU-DIPG-VI and SU-DIPG-XIII cells combined, shown as log-transformed counts per million (CPM). c, Violin plots of relative expression of TrkB isoforms (depicted in a,) separated by patient-derived xenograft model type (SU-DIPG-VI (D6) and SU-DIPG-XIII (D13)). Y-axis is in log-transformed counts per million (CPM).
