Extended Data Fig. 8: The transcriptional regulation of myogenesis in human and mouse.
From: A human embryonic limb cell atlas resolved in space and time
a, Dot plot showing expression level of transcription factors per cell cluster in humans, coloured by group (green, first myogenesis; pink, second myogenesis; yellow, both). The colour bar indicates the linearly scaled mean of expression level. MyoProg, myogenic progenitor; MyoB, myoblast; MyoC, myocyte. b, Force-directed graph showing muscle populations per time point. c, Force-directed graph showing the expression of PITX1 between forelimb (left panel) and hindlimb (right panel) in cells derived from mesenchyme and skeletal muscle lineage. The expression level of genes is the normalised and logarithmic value of raw counts. d, Force-directed graph of human and mouse skeletal muscle cells, coloured by cell clusters. e, Stacked bar chart showing the fraction of mouse cell clusters per time point, followed by the colour code of mouse cell clusters in d. f, Scatter plots of PAX3 and PAX7 expression (normalised and log-transformed) in mouse and human skeletal muscle cells. The percentages of double positive cells are given. g, Force-directed graph of mouse cells per time point, coloured by cell cluster in d. h, Dotplots of selected genes expressed in humans and mice. The colour bar indicates linearly scaled average expression levels.
