Extended Data Fig. 17: LIM-defined pontomedullary reticulospinal neurons have varying levels of complexity.
From: A transcriptomic taxonomy of mouse brain-wide spinal projecting neurons
a, Constellation plot showing global relatedness across all pontomedullary ReSNs. Each transcriptomic type is represented by a node whose area represents the number of nuclei (log-scale). Nodes are positioned at the centre of the corresponding type in UMAP space in Fig. 4a. Relationships between nodes are indicated by edges. Shading behind plot indicates LIM group. Number labels and colors on nodes correspond to type number from Fig. 1c. b, Average distance to the K nearest neighbors (KNN) for each nucleus. Nuclei in highly homogenous clusters have much shorter distance to their KNN compared to nuclei in highly heterogenous clusters. This metric can be used to measure the local heterogeneity of each nucleus regardless of their cell type identities.
