Extended Data Fig. 4: circFAM53B-transfected DCs were capable of eliciting anti-tumour immune response in breast cancer PDXs.
From: Tumour circular RNAs elicit anti-tumour immunity by encoding cryptic peptides
(a) Tumour volumes were monitored weekly following the infusion of DCs and T cells (SYMH178: n = 4 per group; SYMH187: n = 4 per group). (b, c) Representative immunofluorescent images and quantitation of CD8 and GZMB co-staining (b), as well as TUNEL and CK (c) co-staining in collected PDXs. Scale bars, 50 μm. ND, not detected. (b) ***P = 0.0005 (SYMH169), 0.0006 (SYMH178), 0.0002 (SYMH187). (c) ***P = 0.0005 (SYMH178), 0.0002 (SYMH187). Results are mean ± s.d. of n =  3 mice per group per PDX case (b, c) producing similar results. ****P <  0.0001. P values, compared with mice without cell transfusion (no transfusion) (a, c), mice transfused with mock-transfected DCs and T cells (b), were determined by two-tailed one-way ANOVA with Dunnett’s multiple-comparisons test (a-c).
