Extended Data Fig. 7: Human enhancer design by in silico evolution.

a, Prediction scores for the top 50 DNase tracks for MEL EFS sequences. The four first DNAse tracks are: foreskin melanocyte male newborn, SK-MEL-5, foreskin melanocyte male newborn, SK-MEL-5. b, Enformer prediction tracks for three classes and ChromBPNet MM001 ATAC prediction tracks (right) for melanoma EFS-1 (top) and EFS-8 (bottom) sequences added in place of the IRF4 enhancer. c, Enformer prediction tracks for three classes for melanoma EFS-4 sequences added 10 kb upstream, 5 kb upstream or 17.5 kb downstream of the IRF4 enhancer. In b, c, top track: random sequence prediction score, other tracks: delta of mutated sequence prediction score vs random sequence prediction score.