Extended Data Fig. 7: Regulation of human and murine ligand-activated transcription factors by bile acids.
From: Bile salt hydrolase catalyses formation of amine-conjugated bile acids
(a) Luciferase reporter assays for activation of human transcription factors FXR, VDR, CAR3, PXR, AHR, and PPARα, β/δ, and γ by a 50 µM dose of conventional and bacterially conjugated bile acids. (b) Luciferase reporter assays for activation of mouse nuclear receptors FXR and PPARα, β/δ, and γ by a 50 µM dose of conventional and bacterially conjugated bile acids. Differences between treatments and vehicle-treated control were determined using ANOVA with Dunnett’s post-hoc test (p < 0.05*), n = 3 per group. Color gradient is on a log scale.
