Extended Data Fig. 9: Overexpression and KD of TDP-43 partly recapitulate transcriptomic alterations observed in affected neurons in FTLD-ALS patients.
From: A model of human neural networks reveals NPTX2 pathology in ALS and FTLD
a, 4-way comparisons demonstrating the overlap of genes that are significantly altered in both TDP-43 KD (vs Ctrl shRNA) iNet neurons and in TDP-43-negative FTLD-ALS patient neurons (vs TDP-43-positive)38 (left), TDP-43-HA ON (vs OFF) iNet neurons and in TDP-43-negative FTLD-ALS patient neurons (vs TDP-43-positive) (middle), TDP-43-HA ON (vs OFF) and TDP-43 KD (vs Ctrl shRNA) iNet neurons (right). b, Venn diagrams visualizing the overlap of significantly downregulated (left) or upregulated (right) genes from all 3 conditions in (a). OE = overexpression, KD = knockdown.
