Fig. 2: iNets partially resemble brain organoids.
From: A model of human neural networks reveals NPTX2 pathology in ALS and FTLD
a, UMAP of young, middle stage and old iCoMoNSC-derived iNets. Colours highlight manually annotated clusters. Grey arrows indicate direction of neuronal or astrocytic or glial progressive maturation across all samples. b,c, UMAP data from a, annotated according to experimental (b) or predicted (c) cell cycle stage. d,e, UMAPs data from a integrated with organoid datasets highlighting the experimental stage origin (d) or clusters consisting of both iCoMoNSC and organoid cells (e). f, Cell distribution across all clusters. Stars indicate clusters with cell composition of at least 10% per origin. Cluster names as in e. Clusters with less than 10% of cells per origin: (1) iCoMoNSCs, (2) iPS cells, (3) iCoMoNSCs, (6) neuroepithelial-like/retina progenitors, (11) cycling ventral and dorsal neurons, (13) cortical neurons/ventral progenitors, (14) oligodendrocyte progenitor cells (OPCs), (18) maturing neurons and (20) iPS cells.
