Fig. 3: Metabolic trait-associated variants are associated with ICP.

a,b, Manhattan plot of the GWAS of intrahepatic cholestasis of pregnancy (ICP) (a) and heat map of loci associated with metabolic traits and ICP (b). Twelve loci were associated with ICP in the FinnGen study (1,460 cases, 172,286 controls). a, The 500-kb regions flanking the lead SNPs are highlighted, and the nearest gene is indicated for each signal. The ICP GWAS was performed with scalable and accurate implementation of generalized mixed model (SAIGE). Loci that overlap with the loci identified in the NMR meta-analysis are indicated in red. b, Loci that are likely to have shared causal variants with the metabolic traits are included. The heat map illustrates the resemblances of the association landscapes. Each row represents a single SNP, each column corresponds to a single metabolic measure, and the scaled effect estimates for the SNP–metabolite associations from inverse variance-weighted GWAS meta-analysis are represented as a colour range. The associations were scaled with respect to their associations with ICP (s.d. change per ICP odds ratio (OR) 1.5). Detailed descriptions of the metabolic traits and abbreviations are shown in Supplementary Table 2.