Extended Data Fig. 2: Mirrored Manhattan plot showing the results of genome-wide association study of phenylalanine in the NMR GWAS meta-analysis and UK Biobank.
From: Genome-wide characterization of circulating metabolic biomarkers
The top panel of the mirrored Manhattan plot shows the NMR inverse variance weighted GWAS meta-analysis results (n = 136,016) and the bottom panel the UKBB results (n = 115,025). The red lines indicate the thresholds for genome-wide significance (top panel p < 1.8 × 10−9; bottom panel p < 5 × 10−8). 500-kb regions around lead SNPs in the NMR GWAS are highlighted. Loci indicated in red have roles in coagulation-related pathways. Loci indicated in blue were genome-wide significant in both NMR GWAS meta-analysis and UK Biobank.
