Fig. 1: Cryo-EM reconstructions of the human Vγ9Vδ2 and Vγ5Vδ1 TCR–CD3 complexes. | Nature

Fig. 1: Cryo-EM reconstructions of the human Vγ9Vδ2 and Vγ5Vδ1 TCR–CD3 complexes.

From: Structures of human γδ T cell receptor–CD3 complex

Fig. 1

a, The structurally resolved Vγ9Vδ2 TCR–CD3 complex contains TCRγ9 (hot pink), TCRδ2 (purple), CD3ε (pale blue), CD3γ (brown), CD3δ (yellow green) and CD3ζ (teal). An extracellular view (contoured at 5σ) is shown. Inset: cross-section of the TMD of the Vγ9Vδ2 TCR–CD3 complex. The colour scheme in a is used throughout the other figures. b, The overall cryo-EM map (contoured at 2σ) of the dimeric human Vγ5Vδ1 TCR–CD3 complex. Each protomer contains an ECD, MPD and TMD. The cryo-EM maps of ECDs, MPDI–TMDI and MPDII–TMDII, which are contoured at 9σ, 8σ and 8σ, respectively, are individually docked into the cryo-EM density (left). The composite cryo-EM maps were rendered using the same colour scheme as in a (right). All of the structural figures were prepared using UCSF ChimeraX51 unless otherwise indicated.

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