Fig. 4: The Vγ5Vδ1 TCR–CD3 complex is an asymmetric dimer.
a, The Vγ5Vδ1 TCR–CD3 complex displays an asymmetric dimeric assembly. Two protomers are nestled against each other through the Vγ5 domains. The unresolved loops in the Vγ5Vδ1 TCR–CD3 complex are indicated by dashed lines. b, TCRγ5 and TCRδ1 are asymmetrically arranged. The ECD of Vγ5Vδ1 TCR–CD3 pivots around along the axis vertical to the membrane, suspending over the membrane. The vertical distance between the ECD and TMD is indicated by solid and dashed lines. c, An extracellular view of the Vγ5Vδ1 TCR–CD3 complex. The Cγ5II and Cδ1II domains are positioned directly above the TMDII, while the Cγ5I and Cδ1I domains display a lateral deviation by about 45 Å from the TMDI. d, MPDI–TMDI and MPDII–TMDII are arranged with a relatively flexible angle. An extracellular view is shown.
