Extended Data Fig. 4: Pdcd1 is increased in TAMs in many types of cancers.
From: Obesity induces PD-1 on macrophages to suppress anti-tumour immunity
a, Pdcd1 expression within tumor immune cells subsets from scRNAseq within TISCH2 database. b-c, Pdcd1 expression in CD8 T effector and Monocyte/Macrophage identified cells in the TISCH2 scRNAseq database from various cancer datasets. d, Percent Pdcd1+ macrophages from human ccRCC tumor samples measured using gene expression from scRNAseq dataset (n = 11 patients) e, Percent Pdcd1+ macrophages of human CRC tumor samples quantified using gene expression from scRNAseq (n = 62 patients) f-g, Percent Pdcd1+ macrophage cells corresponding to pathological tumor grade compared to adjacent normal tissue from human CRC or human ccRCC tumor samples measured using gene expression from scRNAseq. h, Enrichment of KEGG metabolic signature scores of Pdcd1− versus Pdcd1+ TAMs from human CRC scRNAseq. Data are mean ± s.e.m. P values were calculated using an unpaired two-tailed t-test. *p ≤ 0.05, **p ≤ 0.01.
