Extended Data Fig. 3: Transcriptomic clustering and proteomic analysis of activated CAR T cells.

a, Cell proportion comparison in each identified cluster of the Discovery Cohort UMAP (Fig. 2a) across persistence groups. b, Expression distribution of Memory Score on the Discovery Cohort UMAP in Fig. 2a, and the cell proportion comparison in Cluster 0. c, Heatmap showing the average expression levels of ADT proteins in all activated CAR T cells within each BCA group. d, Expression distribution of each gene defining the Type-1 and Type-2 Score on the Discovery Cohort UMAP in Fig. 2a. e, Cell proportion comparison in each identified cluster of the Validation Cohort UMAP (Fig. 2c) across persistence groups. f, Expression distribution of Memory Score on the Validation Cohort UMAP in Fig. 2c, and the cell proportion comparison in Cluster 0. g, Expression distribution of each gene defining the Type-1 and Type-2 Score on the Validation Cohort UMAP in Fig. 2c. In b and f, genes defining the module are listed below. Scatter plot shows mean ± s.e.m. from n = 48 (b) and n = 46 (f) patients or healthy donors. Significance levels were calculated with two-tailed Mann-Whitney test (b, f).