Extended Data Fig. 4: Comparison of parental age.
From: De novo variants in the RNU4-2 snRNA cause a frequent neurodevelopmental syndrome
Comparison of (a) paternal age for probands with fathers and (b) maternal age for probands with mothers recruited into GEL for individuals with variants in RNU4-2 (teal) and all other NDD probands (grey). Centre line, median; box limits, upper and lower quartiles; whiskers, 1.5x interquartile range. Individual data points, including outliers, are not shown due to Genomics England restrictions. NS: not significant. Paternal age: mean 33.1 vs 33.4 in individuals with RNU4-2 variants and other NDD probands, respectively (two-sided t-test P-value = 0.771; t = −0.29 (−2.41 - 1.80)). Maternal age: mean 30.2 vs 29.7 in individuals with RNU4-2 variants and other NDD probands, respectively (two-sided t-test P-value = 0.505; t = −0.67 (−1.07 - 2.15)).
