Extended Data Fig. 5: A laminar-specific circuit for InhTC^dist cells.

a) Morphology of all InhTC that preferentially target DistTCs. Cells are sorted by soma depth. b) Connectivity dotplot for synapses from InhTC^dist onto DistTCs. In the grid, each dot represents a connection from one InhTC onto one DistTC, with the number of synapses indicated by dot size. The ___location of the dot corresponds to the soma depth of the pre- and post-synaptic cells. Stem plots on top and side indicate the net synaptic inputs and net synaptic outputs of each InhTC^dist and DistTC. Note that DistTCs in layer 2/3 receive little input from InhTCs, compared to those in layer 4 and upper layer 5. c) Connectivity scatterplot for synapses from DistTCs onto InhTC^dist, as in b. Note that the DistTCs in layer 2/3 also form few synaptic outputs onto InhTC^dist. d) Distribution across M-types of synaptic outputs across low-connection DistTCs and high-connection DistTCs. e) Connectivity cartoon suggested by this data.