Extended Data Fig. 8: MICL regulates NET formation during fungal infection.
From: Recognition and control of neutrophil extracellular trap formation by MICL
a, Representative Sytox green fluorescent (DNA, green) and calcofluor white (blue) images of A. fumigatus-induced NETs in bone marrow neutrophils isolated from WT or MICL-deficient animals and quantification as percentage of neutrophils under NETosis (3 fields of view per condition) at 4 h post-stimulation. Statistical significance determined by student’s t-test. b, Tissue fungal burdens of mice two days after intravenous (i.v) infection with 106 A. fumigatus conidia (values shown are mean± SEM of pooled data from two independent experiments, n = 14 biologically independent mice). c, Survival of mice following i.v infection with 106 A. fumigatus conidia and treated with vehicle control (n = 1 experiment with 6 mice/group) analysed by log-rank test. p = 0.0195. CFU, colony-forming unit. *, p < 0.05.
