Extended Data Fig. 8: Data related to Fig. 4.
From: AKT and EZH2 inhibitors kill TNBCs by hijacking mechanisms of involution
a, immunoblot of FOXO1 and pFOXO1 expression in TNBC cell lines treated with EZH2i and/or AKTi. Experiment was repeated at least 3 times. b, RT-qPCR of FOXO1 expression after EZH2i and/or AKTi treatment in three sensitive TNBC cell lines. Values indicate z scores of three independent biological samples. c, genome browser view of FOXO1 locus with CUT&RUN data using H3K27me3 and H3K4me3 antibodies in chromatin from MDA-MB-468 cells treated with EZH2i and/or AKTi. d, genome browser view of GATA3 promoter with FOXO1 ChIP-seq occupancy (accessed from ENCODE). e, genome browser view of GATA3 enhancer with FOXO1 ChIP-seq occupancy (accessed from ENCODE).
