Extended Data Fig. 10: Minimum VAF in either donor or recipient myeloid cells.

a, Combined phylogeny for Pair_9, with mutations coloured by the lower value of the estimated posterior median VAF in granulocytes from either the donor or the recipient. This means any coloured branch is detectable in both donor and recipient, including several of the clonal expansions. Trees have been made ultrametric and scaled to chronological age. Shaded grey box indicates approximate time of HCT. b, As in a, but for Pair_7. c, As in a, but for Pair_5. d, Estimated dN/dS ratios combined across pairs, split by mutations found in donors or recipients and mutation type, corrected for expected freuqncy based on background mutation rates, sequence context and chromatin state. A dN/dS ratio of >1.0 implies more positive than negative selection; a ratio <1.0 implies more negative than positive selection. Circles denote point estimates and bars denote 95% confidence intervals estimated across mutations called from n = 10 donor-recipient pairs.