Extended Data Fig. 11: NRF2 activation and FBP1 loss enable propagation of NRAS induced mutations. | Nature

Extended Data Fig. 11: NRF2 activation and FBP1 loss enable propagation of NRAS induced mutations.

From: FBP1 controls liver cancer evolution from senescent MASH hepatocytes

Extended Data Fig. 11

a, INDEL types in HCCs from MUP-uPA/Fbp1ΔHep mice fed HFrD or HFD for 40 weeks. b, Mutational signatures displayed based on trinucleotide frequency of HFD-induced MUP-uPA/Fbp1ΔHep HCCs (1 tumour per run). c, d Duplex sequencing showing the number of mutations (c) and INDELs (d) in each signature in the indicated mice. NT- non-tumour, T-tumour. e, Number of mutations in each INDEL signature expressed as somatic mutations per megabase in HCCs from NRASG12V transduced Nrf2Act-Hep livers. f, g, Number of mutations and INDEL types in HCCs of NRASG12V transduced Nrf2Act-Hep livers for 16 weeks.

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