Extended Data Fig. 4: PDCD5 structures and densities of the open TRiC map.
From: In situ analysis reveals the TRiC duty cycle and PDCD5 as an open-state cofactor
a, NMR structure of PDCD5 (1 – 112 a.a.). The five helices of PDCD 5 were labelled as α1 to α5. b, Overlay of PDCD5 at different conformations (PDB 2K6B). c, Overlay of the AlphaFold predicted model of PDCD5 (PDCD5, AF-O14737-F1, full length, 1 – 125 a.a.) with PDB 2K6B coloured in grey. AlphaFold produces a per-residue model confidence score (predicted local distance difference test, pLDDT) between 0 and 100. Very high (blue, pLDDT > 90), High (light blue, 90 > pLDDT > 70), Low (yellow, 70 > pLDDT > 50), Very low (orange, pLDDT < 50). d, The additional density that was not modelled by in vitro studies of TRiC. The density was fitted with the AlphaFold predicted model of PDCD5.
