Fig. 3: Mutation spectra.
a, Mutation spectra for phased DNMs proximal to oNCOs and genome-wide. DNMs were considered to be proximal to oNCOs if they were within 3 kb and 100 kb for paternally and maternally phased DNMs, respectively. The length of the bars indicates the mutation class fraction for the complete cohort of the study. Error bars show 95% confidence intervals computed by bootstrapping 1,000 samples; asterisks indicate mutation classes in which the NCO-proximal and genome-wide spectra were significantly different (P < 0.05, bootstrap test). b, Strand asymmetry for phased DNMs around oNCOs. L and R denote DNMs to the left and right of the oNCO centre, respectively.
