Extended Data Fig. 8: CRISPRa-mediated overexpression of Sash3, Tlr7 and Cysltr1 in old mice did not alter measures of anxiety in the EPM or swim speed in the MWM.
From: The maternal X chromosome affects cognition and brain ageing in female mice
a, Anxiety-like behavior, measured by % time in open arm, did not differ between groups at either 5 or 10 min (Control mice: n = 14; CRISPRa+ mice: n = 13; age = 19 months). b, Total distance traveled in the EPM, did not differ between groups at either 5 or 10 min (Control mice: n = 15; CRISPRa+ mice: n = 14; age = 19 months). c, Swim speed did not differ between the experimental groups, measured during the visible platform trials (Control mice: n = 15; CRISPRa+ mice: n = 14; age = 20 months), Unpaired two-tailed t-test, P > 0.05. d, Latency to find a visible platform did not differ between the experimental groups (Control mice: n = 15 (session 1), n = 14 (session 2); CRISPRa+ mice: n = 15 (session 1), n = 14 (session 2); age = 20 months). Two-way mixed model ANOVA: genotype P > 0.05. Data represent means ± SEM.
