Fig. 4: Manipulating COAplEsr1 cells alters connectivity in the pink module. | Nature

Fig. 4: Manipulating COAplEsr1 cells alters connectivity in the pink module.

From: A crucial role for the cortical amygdala in shaping social encounters

Fig. 4

a, Experimental timeline. b,c, Inhibition of of COAplEsr1 cells reduces attack duration (b; t(38) = 3.731, P = 0.0006) and increases investigation duration (c; t(38) = 4.719, P < 0.0001). d,e, The mCherry network showed higher expression of the pink module (d; t(38) = 4.442, P < 0.0001) when the two networks were combined, and preserved the connectivity and density of the pink module better than the hM4Di network did (e; t(9) = 3.983, P = 0.0032) when they were separately analysed. Each pair of points connected by a line is a single preservation metric from each network (n = 19 (HM4di) and n = 21 (mCherry)). f, Whole-brain FOS network in mice injected with mCherry or hM4Di .g, Network plot of the pink module in mice injected with mCherry (top) or with hM4Di (bottom), from the wild-type AGG network. Regions from the mCherry and hM4Di networks were plotted using the colour label from the original network. h, Of the 28 regions in the pink module, inhibition of COAplEsr1 cells significantly decreased FOS expression in 24 regions (86%). Network analyses were replicated in two cohorts. *P < 0.05, **P < 0.01, ***P < 0.001 (n = 21 mCherry and n = 19 HM4Di). All data are mean ± s.e.m. The illustrations in a were created with BioRender.

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