Extended Data Fig. 12: Schematic illustration of the mechanism of MA and CA maturation.
From: The conserved HIV-1 spacer peptide 2 triggers matrix lattice maturation
In the immature virus, MA and CA both form ‘immature’ hexameric lattices. Upon viral maturation, which is initiated by the activation of the viral protease (PR), Gag is cleaved into its constituent domains; MA, CA, SP1, NC, SP2 and p6. In the case of MA, subsequent structural transition to the mature lattice is induced upon binding of cleaved SP2 to MA. In the case of CA, cleavage of SP1 leads to the release of IP6 which binds free CA to promote the formation of the mature CA lattice. Virus schematics adapted from Briggs and Kräusslich (2011)70.
