Extended Data Fig. 4: Optogenetic activation of SNr neurons delays lever pressing.
From: Dynamic basal ganglia output signals license and suppress forelimb movements
a, Bar plot displaying the mean and standard error thereof of the control normalized response rate upon optogenetic activation of SNr neurons with the two approaches detailed in Fig. 4b. Single dots represent single mice (all mice n = 15, SNr>latRM n = 6, PPN>SNr n = 9). b, Average and standard error of the mean of the cumulative distribution of latency to press in laser (blue) and control (grey) trials across mice for SNr>latRM activation (left) and optogenetic activation of PPN>SNr excitatory projections. Thin lines represent single mouse data. c, Bar plot displaying the mean and standard error thereof of the control normalized response rate in control mice expressing eGFP in either the PPN or SNr neurons with an optic fibre implanted in the PPN or SNr respectively to control for the effects of light on the performance of the mice (n = 4) (left). Average and standard error of the mean of the cumulative distribution of latency to press in laser (blue) and control (grey) trials across all control mice (middle). No effect was observed in the press rate or the latency to press the lever in the control mice upon the exposure of the cells to the laser light. Mean control subtracted press rate (black) during laser trials (blue shade) in the control mice showed no stereotyped change in press rate across the control mice (right) over the response window.
