Supplementary Figure 13: Rag1 and Rag2 knockout cells fall into the wild-type developmental manifold of T-cell maturation.
From: Inferring population dynamics from single-cell RNA-sequencing time series data
(a-c) Diffusion map projections of the combined wild-type and knock-out data sets show that the knockout cells lie within the wild-type manifold in each projection. KO: knockout, WT: wild-type. (d) The overall structure of the manifold is conserved between a diffusion map computed just on wild-type and one computed on wild-type and mutant samples: Scatter plot of diffusion pseudotime coordinates of wild-type cells in wild-type only (WT) and in wild-type with mutants (WT+RagKO) data sets.
