Extended Data Fig. 8: Predicting translocation-induced chromatin organizations and neo-TADs in K562 cells. | Nature Biotechnology

Extended Data Fig. 8: Predicting translocation-induced chromatin organizations and neo-TADs in K562 cells.

From: Cell-type-specific prediction of 3D chromatin organization enables high-throughput in silico genetic screening

Extended Data Fig. 8

a–c, Experimental and predicted Hi-C matrices at three translocation loci in K562 cells. In each case, chromatin organization structures were first reconstructed using HiC-bench56 and NeoLoopFinder37, followed by C.Origami prediction at the translocation loci using in silico fused genomic information. a, t(22;9) translocation, also known as the Philadelphia chromosome, that leads to a fused gene BCR-ABL1. b, t(21;12) translocation with a stripe interaction. c, t(3;10) translocation with a faint ‘L’-shape interaction as indicated by the dotted contour. Dotted boxes indicate neo-TAD forming at the translocation site. Black arrowhead indicates the translocation site.

Back to article page