Extended Data Fig. 3: Dox treatment does not induce abnormalities in iBEhom mice.
From: Generation of precision preclinical cancer models using regulated in vivo base editing
a. Hematoxylin and Eosin (H&E) staining in rtTA3+/-iBE-/- and rtTA3+/+iBE+/+ (iBEhom) on normal chow or doxycycline chow for 14 days. (n=3 mice). b. Flow cytometry analysis of spleen and bone marrow cell suspensions of rtTA3+/-iBE-/- and rtTA3+/+iBE+/+ (iBEhom) on normal chow or maintained on doxycycline chow for 14 days (n=3 mice). Data are presented as mean values ± s.d (*p<0.05, Student’s t-test).
