Extended Data Fig. 5: Characterization of PE-eVLPs. | Nature Biotechnology

Extended Data Fig. 5: Characterization of PE-eVLPs.

From: Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo

Extended Data Fig. 5

a, Comparison of prime editing efficiency (% editing) and insertion-deletion byproduct generation (% indel) of PE3 system delivered by plasmid transfection versus v3 PE3-eVLP. PE3 system targets Dnmt1 locus in N2A cells. Data represent the average prime editing efficiency of three biological replicates and error bars represent the standard deviation. b, Prime editing efficiencies at Dnmt1 locus in N2A cells and HEK3 locus in HEK293T cells from treatment with four independent batches of v3 PE3-eVLPs produced on different days, with each dot indicating the prime editing efficiency of each of the four v3 PE3-eVLP batches. Data shown represent the mean prime editing efficiency from four different v3 PE3-eVLP batches and error bars represent the standard deviation.

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